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Phase I Study of Pooled Mutant KRAS-Targeted Long Peptide Vaccine Combined With Nivolumab and Ipilimumab for Patients With Resected MMR-p Colorectal and Pancreatic Cancer

Summary

11/28/2021 Note: Enrollment slots filled until Jan 2022. Please inquire with study team. The purpose of this phase I study is to evaluate the safety and the immune response to pooled mutant-KRAS peptide vaccine (KRAS peptide vaccine) with poly-ICLC adjuvant in combination with nivolumab and ipilimumab in patients with resected PDAC and patients with metastatic MSS CRC who have progressed on 2 or more lines of chemotherapy.

General Information

NCT#: NCT04117087
Study ID: J1994
Trial Phase: Phase I

Trial Sponsor: Bristol-Myers Squibb, Sidney Kimmel Comprehensive Cancer Center
Therapies Used in This Trial: Ipilimumab, Hiltonol®, Nivolumab

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