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Phase II, Open-label, Randomized, Comparative Study of Combination Immunotherapy Plus Standard-of-Care Chemotherapy Versus Standard-of-Care Chemotherapy for First and Second Line Treatment of Locally Advanced or Metastatic Pancreatic Cancer

Summary

This is a phase II, randomized, two-cohort, open-label study to evaluate the comparative efficacy and overall safety of standard-of-care chemotherapy versus standard-of-care chemotherapy in combination with aldoxorubicin HCl, N-803, and PD-L1 t haNK in subjects with locally advanced or metastatic pancreatic cancer. Each treatment setting (ie, first line maintenance, or second or later line) will be evaluated independently as a separate cohort.

General Information

NCT#: NCT04390399
Study ID: QUILT-88
Trial Phase: Phase II

Trial Sponsor: ImmunityBio, Inc.
Therapies Used in This Trial: Nab-paclitaxel, Fluorouracil, Gemcitabine, Stereotactic body radiotherapy (SBRT), Cyclophosphamide, Leucovorin, irinotecan liposome injection, Aldoxorubicin, ALT-803/N-803, PD-L1 haNK

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