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Phase I Study of Losartan and Hypofractionated Radiation Therapy After Induction Chemotherapy for Borderline Resectable or Locally Advanced Pancreatic Cancer (SHAPER)

Summary

The purpose of this phase I trial is to study the side effects of losartan and hypofractionated radiation therapy after chemotherapy in treating patients with pancreatic cancer that may or may not be removed by surgery (borderline resectable) or has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection (locally advanced unresectable). Losartan may improve blood flow and allows for better tissue oxygenation. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects. Giving losartan and hypofractionated radiation therapy may work better in treating patients with pancreatic cancer compared to hypofractionated radiation therapy alone.

General Information

NCT#: NCT04106856
Study ID: HCI121104
Trial Phase: Phase I

Trial Sponsor: National Cancer Institute (NCI), University of Utah
Therapies Used in This Trial: Losartan, Hypofractionated radiation therapy

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