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Phase Ib/II Study To Evaluate Safety And Clinical Activity Of Avelumab In Combination With Binimetinib With Or Without Talazoparib In Patients With Locally Advanced Or Metastatic RAS-mutant Solid Tumors

Summary

The purpose of this phase Ib/II study is to examine the effects of the study drugs, avelumab and binimetinib given together (doublet) and in combination with talazoparib (triplet), in patients with locally advanced or metastatic RAS-mutant solid tumors. The Phase Ib part of the study will assess if the different study drugs can be given together safely and which doses to use for further research. Phase II will test if the study treatments have an effect on tumor size and growth, and gather more information about potential side effects.

General Information

NCT#: NCT03637491
Study ID: B9991033
Trial Phase: Phase I/II

Trial Sponsor: Pfizer, Array Biopharma
Therapies Used in This Trial: Binimetinib, Avelumab, Talazoparib

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Site Information


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