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Phase I Trial of Ulixertinib (BVD-523) in Combination With Palbociclib in Patients With Advanced Solid Tumors With Expansion Cohort in Previously Treated Metastatic Pancreatic Cancer

Summary

02/11/2021 NOTE: This trial is currently enrolling in the second part of the trial (expansion cohort). The purpose of this phase I study is to establish the safety, maximally tolerated dose (MTD) and recommended phase II dose (RP2D) of the ERK inhibitor ulixertinib (BVD-523) when combined with the CDK4/6 inhibitor palbociclib.

General Information

NCT#: NCT03454035
Study ID: LCCC1736
Trial Phase: Phase I

Trial Sponsor: Pfizer, BioMed Valley Discoveries, UNC Lineberger Comprehensive Cancer Center
Therapies Used in This Trial: Palbociclib, Ulixertinib

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