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Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of a Neoantigen DNA Vaccine Strategy in Pancreatic Cancer Patients Following Surgical Resection and Adjuvant Chemotherapy

Summary

The purpose of this phase I open-label study is to evaluate the safety and immunogenicity of a neoantigen DNA vaccine strategy in pancreatic cancer patients following surgical resection and adjuvant chemotherapy. The neoantigen DNA vaccines will incorporate prioritized neoantigens and personalized mesothelin epitopes and will be administered with an electroporation device. The hypothesis of this study is that neoantigen DNA vaccines will be safe and capable of generating measurable neoantigen-specific CD4 and CD8 T cell responses.

General Information

NCT#: NCT03122106
Study ID: 201708105
Trial Phase: Phase I

Trial Sponsor: Washington University
Therapies Used in This Trial: neoantigen DNA-based pancreatic cancer vaccine

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