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Phase II Study of Entrectinib for the Treatment of Patients With Locally Advanced or Metastatic Solid Tumors That Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements (STARTRK-2)

Summary

The purpose of this phase II study is to determine the safety and efficacy of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1/2/3, ROS1, or ALK gene rearrangement. Patients will be assigned to different baskets according to tumor type and gene rearrangement. NOTE: Ignyta covers the cost of biomarker testing performed during screening for the trial. Ignyta also offers to reimburse the cost of travel and accommodation if a patient is eligible to participate in the study. Entrectinib is approved for expanded access for patients who do not qualify for participation in, or who are otherwise unable to access, an ongoing clinical trial for Entrectinib (www.startrktrials.com).

General Information

NCT#: NCT02568267
Study ID: RXDX-101-02
Trial Phase: Phase II

Trial Sponsor: Hoffmann-La Roche
Therapies Used in This Trial: Entrectinib

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