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Phase II Trial of Targeted Therapy Directed by Genetic Testing in Treating Patients with Advanced Refractory Solid Tumors or Lymphomas (NCI-MATCH)

Summary

Due to the high volume of sites for this trial, please note that some of the sites may no longer be accruing. We update this information as we become aware of site closures; please contact the site for verification.

The purpose of this phase II trial is to study how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for whom no standard treatment exists.
Patients with specific, pre-defined mutations, amplifications, or translocations of interest via tumor sequencing and immunohistochemistry are assigned to 1 of 26 treatment sub-protocols based on their molecularly-defined subgroup.

Biomarker testing to determine if patient is eligible and which treatment each patient will receive must be completed prior to screening for the trial. Patients must undergo molecular profiling from designated commercial or academic laboratories listed here: http://ecog-acrin.org/nci-match-eay131-designated-labs

General Information

NCT#: NCT02465060
Study ID: EAY131
Trial Phase: Phase II

Trial Sponsor: National Cancer Institute (NCI)
Therapies Used in This Trial: Vismodegib, Dasatinib, Pertuzumab, Sunitinib, Trastuzumab, Trametinib, Sapanisertib, Afatinib, Crizotinib, Palbociclib, Larotrectinib, Osimertinib, Erdafitinib, Copanlisib

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