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Phase I Study Combining Nab-Paclitaxel With Capecitabine and Radiation Therapy for Consolidation of Treatment Following Induction Chemotherapy for Locally Advanced Pancreatic Cancer

Summary

The purpose of this phase I trial is to study the side effects and best dose of nab-paclitaxel when given together with capecitabine and radiation therapy following first treatment with chemotherapy (induction therapy) in treating patients with pancreatic cancer that is not spread to tissue far away but is not operable due to abutment or encasement of blood vessels nearby (locally advanced). Drugs used in chemotherapy, such as nab-paclitaxel and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving nab-paclitaxel, capecitabine, and radiation therapy together may kill more tumor cells.

General Information

NCT#: NCT02394535
Study ID: 2014-0469
Trial Phase: Phase I

Trial Sponsor: Celgene Corporation, M.D. Anderson Cancer Center
Therapies Used in This Trial: Nab-paclitaxel, Radiation Therapy, Capecitabine

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