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Phase I/II Trial of Combination Immunotherapy With Nivolumab and a CCR2/CCR5 Dual Antagonist (BMS-813160) With or Without GVAX Following Chemotherapy and Radiotherapy for Locally Advanced Pancreatic Ductal Adenocarcinomas (PDACs)

Summary

05/20/2020 NOTE: Patients interested in this study must call the site to inquire about participation, as there may be COVID-19 restrictions in place. The purpose of this phase I/II study is to evaluate if the combination of nivolumab and a CCR2/CCR5 dual antagonist (BMS-813160) with GVAX is safe in patients with locally advanced pancreatic cancer (LAPC) who have received chemotherapy and radiotherapy, and to see if this combination therapy enhances the infiltration of CD8+CD137+ cells in PDACs .

General Information

NCT#: NCT03767582
Study ID: J18163
Trial Phase: Phase I/II

Trial Sponsor: Sidney Kimmel Comprehensive Cancer Center
Therapies Used in This Trial: GVAX, Nivolumab, BMS-813160

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