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Phase II Clinical Trial Evaluating Intravenous AZD9150 (Antisense STAT3) With MEDI4736 (Anti-PD-L1) in Patients With Advanced Pancreatic, Non-small Cell Lung Cancer, and Mismatch Repair Deficient Colorectal Cancer

Summary

This phase II trial studies how well danvatirsen (AZD9150) and durvalumab (MEDI4736) work in treating patients with pancreatic cancer, non-small cell lung cancer and mismatch repair deficient colorectal cancer that has spread to other places in the body and does not respond to treatment. Danvatirsen may be used to block the production of proteins needed for tumor cell growth. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving danvatirsen and durvalumab may work better at treating pancreatic cancer, non-small cell lung cancer and mismatch repair deficient colorectal cancer.

General Information

NCT#: NCT02983578
Study ID: 2016-0108
Trial Phase: Phase II

Trial Sponsor: AstraZeneca, M.D. Anderson Cancer Center
Therapies Used in This Trial: Durvalumab, Danvatirsen

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